芳香烃受体信号通路中的遗传多态性作为绝经潮热的潜在风险因素。
Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes.
机构信息
Department of Comparative Biosciences, University of Illinois, Urbana, IL 61802, USA.
出版信息
Am J Obstet Gynecol. 2012 Sep;207(3):202.e9-202.e18. doi: 10.1016/j.ajog.2012.05.019. Epub 2012 Jun 1.
OBJECTIVE
We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels.
STUDY DESIGN
Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were analyzed using multivariable logistic regression and generalized linear models.
RESULTS
Women carrying CYP1B1 (rs1800440) GG genotype had 3-fold greater odds of experiencing hot flashes for ≥1 year compared to the AA genotype (adjusted odds ratio [OR], 3.05; 95% confidence interval [CI], 1.12-8.25). Adding serum estradiol concentrations to the confounder-adjusted model resulted in a nonsignificant association (adjusted OR, 2.59; 95% CI, 0.91-7.18). Carriers of both CYP1B1 (rs1800440) G and CYP1B1 (rs1058636) G alleles had higher odds of experiencing hot flashes for ≥1 year compared to women homozygous for the major alleles (adjusted OR, 1.77; 95% CI, 1.06-2.96), even after adjustment for serum estradiol.
CONCLUSION
CYP1B1 is associated with menopausal hot flashes via pathways that may involve changes in serum estradiol concentration.
目的
我们试图通过激素水平来确定芳香烃受体信号通路的基因多态性是否与绝经后潮热有关。
研究设计
年龄在 45-54 岁的女性（n=639）完成了一项研究调查，并提供了血液进行基因和激素分析。使用多变量逻辑回归和广义线性模型分析了相关性。
结果
与 AA 基因型相比，携带 CYP1B1（rs1800440）GG 基因型的女性发生≥1 年潮热的几率增加了 3 倍（调整后的优势比[OR]，3.05；95%置信区间[CI]，1.12-8.25）。将血清雌二醇浓度添加到混杂因素调整模型中，结果无统计学意义（调整后的 OR，2.59；95%CI，0.91-7.18）。与主要等位基因纯合子的女性相比，携带 CYP1B1（rs1800440）G 和 CYP1B1（rs1058636）G 等位基因的女性发生≥1 年潮热的几率更高（调整后的 OR，1.77；95%CI，1.06-2.96），即使在调整了血清雌二醇后也是如此。
结论
CYP1B1 通过可能涉及血清雌二醇浓度变化的途径与绝经后潮热有关。
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