Neuron. 2012 Jul 26;75(2):182-4. doi: 10.1016/j.neuron.2012.07.002.
While attending medical school at McGill, David Hubel developed an interest in the nervous system during the summers he spent at the Montreal Neurological Institute. After heading to the United States in 1954 for a Neurology year at Johns Hopkins, he was drafted by the army and was assigned to the Neuropsychiatry Division at the Walter Reed Hospital, where he began his career in research and did his first recordings from the visual cortex of sleeping and awake cats. In 1958, he moved to the lab of Stephen Kuffler at Johns Hopkins, where he began a long and fruitful collaboration with Torsten Wiesel. Born in Sweden, Torsten Wiesel began his scientific career at the Karolinska Institute, where he received his medical degree in 1954. After spending a year in Carl Gustaf Bernhard's laboratory doing basic neurophysiological research, he moved to the United States to be a postdoctoral fellow with Stephen Kuffler. It was at Johns Hopkins where he met David Hubel in 1958, and they began working together on exploring the receptive field properties of neurons in the visual cortex. Their collaboration continued until the late seventies. Hubel and Wiesel's work provided fundamental insight into information processing in the visual system and laid the foundation for the field of visual neuroscience. They have had many achievements, including--but not limited to--the discovery of orientation selectivity in visual cortex neurons and the characterization of the columnar organization of visual cortex through their discovery of orientation columns and ocular-dominance columns. Their work earned them the Nobel Prize for Physiology or Medicine in 1981, which they shared with Roger Sperry.
在麦吉尔大学学医期间,大卫·休伯尔(David Hubel)在蒙特利尔神经学研究所度过的暑假期间对神经系统产生了兴趣。1954 年前往美国在约翰霍普金斯大学进行一年的神经病学学习后,他应征入伍,被分配到沃尔特·里德医院的神经精神病学分部,在那里他开始了他的研究生涯,并首次从睡眠和清醒猫的视觉皮层进行了记录。1958 年,他搬到了斯蒂芬·库弗勒(Stephen Kuffler)在约翰霍普金斯大学的实验室,在那里他开始了与托尔斯滕·威塞尔(Torsten Wiesel)的长期而富有成效的合作。托尔斯滕·威塞尔(Torsten Wiesel)出生于瑞典,他在卡罗林斯卡学院开始了他的科学生涯,并于 1954 年获得医学学位。在卡尔·古斯塔夫·伯纳德(Carl Gustaf Bernhard)的实验室进行了一年的基础神经生理学研究后,他移居美国,成为斯蒂芬·库弗勒(Stephen Kuffler)的博士后研究员。正是在约翰霍普金斯大学,他于 1958 年遇到了大卫·休伯尔(David Hubel),并开始合作探索视觉皮层神经元的感受野特性。他们的合作一直持续到 70 年代后期。休伯尔和威塞尔的工作为视觉系统中的信息处理提供了基本的见解,并为视觉神经科学领域奠定了基础。他们取得了许多成就,包括但不限于发现视觉皮层神经元的方向选择性,以及通过发现方位柱和眼优势柱来描述视觉皮层的柱状组织。他们的工作使他们在 1981 年获得了诺贝尔生理学或医学奖,与罗杰·斯佩里(Roger Sperry)分享了这一奖项。