The Portex Unit, UCL Institute of Child Health, Guilford Street, Archway Campus, N19 5LW, London, England, UK.
Int J Colorectal Dis. 2012 Nov;27(11):1485-91. doi: 10.1007/s00384-012-1533-4. Epub 2012 Jul 29.
Aerobic exercise capacity appears impaired in children with inflammatory bowel disease (IBD). Whether this holds true in adults with IBD is not known. Using cardiopulmonary exercise testing (CPET), we assessed anaerobic threshold (AT) in such patients comparing data with reference values and other elective surgical patients. We also sought to confirm whether the presence of a fistula further reduced AT.
CPET was performed between November 2007 and December 2010 on patients awaiting abdominopelvic surgery. Gender-specific normal reference values were used for comparison. Unadjusted comparison between two groups was made using Mann-Whitney U test and by unpaired t test. Data were adjusted by analysis of covariance, using age and sex as covariates. Differences between patients' observed values and reference values were tested using paired t tests.
Four hundred and fourteen patients (234 male) were studied (mean ± SD age, 56.6 ± 16.4 years; weight, 74.2 ± 15.6 kg). Adjusted AT values in Crohn's disease (CD) were lower than colorectal cancer (11.4 ± 3.4 vs 13.2 ± 3.5 ml.kg(-1).min(-1), p = 0.03) and for all other colorectal disease groups combined (12.6 ± 3.5 ml.kg(-1).min(-1), p = 0.03). AT of Ulcerative colitis (UC) and CD patients together were reduced compared to population reference values (p < 0.05).
After adjusting for age and sex, CD patients had a reduced AT compared to patients with colorectal cancer and other colorectal disease groups combined. The pathogenesis of this low AT remains to be defined and warrants further investigation.
在患有炎症性肠病（IBD）的儿童中，有氧运动能力似乎受损。尚不清楚这是否适用于患有 IBD 的成年人。我们使用心肺运动测试（CPET）评估了此类患者的无氧阈（AT），并将数据与参考值和其他择期手术患者进行了比较。我们还试图确认瘘管的存在是否进一步降低了 AT。
2007 年 11 月至 2010 年 12 月期间，对等待腹盆腔手术的患者进行了 CPET。使用性别特异性正常参考值进行比较。使用 Mann-Whitney U 检验和非配对 t 检验对两组之间的未调整比较进行了比较。使用协方差分析对数据进行了调整，使用年龄和性别作为协变量。使用配对 t 检验测试患者观察值与参考值之间的差异。
研究了 414 名患者（234 名男性）（平均 ± SD 年龄，56.6 ± 16.4 岁；体重，74.2 ± 15.6 kg）。调整后的 CD 患者的 AT 值低于结直肠癌（11.4 ± 3.4 与 13.2 ± 3.5 ml.kg(-1).min(-1)，p = 0.03）和所有其他结直肠疾病组的总和（12.6 ± 3.5 ml.kg(-1).min(-1)，p = 0.03）。溃疡性结肠炎（UC）和 CD 患者的 AT 值均低于人群参考值（p < 0.05）。
在调整年龄和性别后，与结直肠癌和其他结直肠疾病组相比，CD 患者的 AT 降低。这种低 AT 的发病机制仍有待确定，需要进一步研究。
