Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland.
Chem Commun (Camb). 2012 Sep 14;48(71):8892-4. doi: 10.1039/c2cc34907h. Epub 2012 Jul 30.
The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.
通过一种新的催化剂结构和更环保的反应方案，改善了手性羟胺酸催化的手性胺动力学拆分的范围、反应性和选择性。除了提高所有底物的选择性外，这些条件还使得能够拆分含有内酰胺或其他碱性官能团的 N-杂环，这些官能团可能会抑制催化剂。
