Yoganathan K, David L, Williams C, Jones K
GU/HIV Medicine, Singleton Hospital, Abertawe Bro Morgannwg University Health Board, Swansea SA2 8QA, UK.
Int J STD AIDS. 2012 Jul;23(7):520-1. doi: 10.1258/ijsa.2011.011408.
A 48-year-old woman with HIV infection developed Cushingoid features while she was taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug interaction between ritonavir and budesonide. Diagnosis of iatrogenic Cushing's syndrome in HIV-positive patients who are on ritonavir-boosted protease inhibitors (PIs) presents a clinical challenge due to similar clinical features of lipohypertrophy related to ritonavir-boosted PIs. Although this complication has been widely described with the use of inhaled fluticasone, the interaction with inhaled budesonide at therapeutic dose is not widely recognized.
一名48岁的HIV感染女性在服用利托那韦增强的达芦那韦时出现了库欣样特征。由于利托那韦与布地奈德之间的药物相互作用，库欣综合征得到确诊。对于正在服用利托那韦增强型蛋白酶抑制剂（PIs）的HIV阳性患者，医源性库欣综合征的诊断面临临床挑战，因为与利托那韦增强型PIs相关的脂肪增生具有相似的临床特征。尽管使用吸入性氟替卡松时这种并发症已被广泛描述，但治疗剂量下与吸入性布地奈德的相互作用尚未得到广泛认识。
