Scott Stephanie H, Bahnson Brian J
Department of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, USA.
Biomol Concepts. 2011 Dec 1;2(6):469-480. doi: 10.1515/BMC.2011.041. Epub 2012 Jul 24.
Senescence marker protein 30 (SMP30) is a multifunctional protein involved in cellular Ca(2+) homeostasis and the biosynthesis of ascorbate in non-primate mammals. The primary structure of the protein is highly conserved among vertebrates, suggesting the existence of a significant physiological function common to all mammals, including primates. Enzymatic activities of SMP30 include aldonolactone and organophosphate hydrolysis. Protective effects against apoptosis and oxidative stress have been reported. X-ray crystallography revealed that SMP30 is a six-bladed β-propeller with structural similarity to paraoxonase 1, another protein with lactonase and organophosphate hydrolase activities. SMP30 has recently been tied to several physiological conditions including osteoporosis, liver fibrosis, diabetes, and cancer. This review aims to describe the recent advances made toward understanding the connection between molecular structure, enzymatic activity and physiological function of this highly conserved, multifaceted protein.
衰老标记蛋白30（SMP30）是一种多功能蛋白，参与非灵长类哺乳动物细胞内的钙稳态和抗坏血酸生物合成。该蛋白的一级结构在脊椎动物中高度保守，这表明包括灵长类动物在内的所有哺乳动物都存在重要的共同生理功能。SMP30的酶活性包括醛糖内酯和有机磷酸酯水解。据报道，它具有抗细胞凋亡和氧化应激的保护作用。X射线晶体学研究表明，SMP30是一种六叶β-螺旋桨蛋白，其结构与对氧磷酶1相似，后者也是一种具有内酯酶和有机磷酸酯水解酶活性的蛋白。最近，SMP30与包括骨质疏松症、肝纤维化、糖尿病和癌症在内的多种生理状况相关。本综述旨在描述在理解这种高度保守、多功能蛋白的分子结构、酶活性和生理功能之间的联系方面取得的最新进展。
