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通过2DICAL进行胰腺癌和胃肠道癌的生物标志物发现：液相色谱和质谱的二维图像转换分析

Biomarker Discovery of Pancreatic and Gastrointestinal Cancer by 2DICAL: 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry.

作者信息

Ono Masaya, Kamita Masahiro, Murakoshi Yusuke, Matsubara Junichi, Honda Kazufumi, Miho Banno, Sakuma Tomohiro, Yamada Tesshi

机构信息

Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

出版信息

Int J Proteomics. 2012;2012:897412. doi: 10.1155/2012/897412. Epub 2012 Jul 10.

DOI:10.1155/2012/897412
PMID:22844596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3400370/
Abstract

Biomarkers tested by blood sample are of great use to clinicians as they provide useful information to aid an early and accurate diagnosis. Comprehensive "omics" studies are expected to facilitate the identification of such new biomarkers, and much research is being performed in this area. Our proteomics analysis system of 2-dimensional image-converted analysis of liquid chromatography and mass spectrometry (2DICAL) has successfully identified several new blood biomarkers from the clinical blood samples of pancreatic and colorectal cancer patients.

摘要

通过血液样本检测的生物标志物对临床医生非常有用，因为它们能提供有助于早期准确诊断的有用信息。综合“组学”研究有望促进此类新生物标志物的识别，目前该领域正在进行大量研究。我们的二维液相色谱和质谱图像转换分析蛋白质组学分析系统（2DICAL）已成功从胰腺癌和结直肠癌患者的临床血液样本中识别出几种新的血液生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/fe9efcc2a455/IJPRO2012-897412.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/304cdfe80efe/IJPRO2012-897412.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/dc4d4cf9c227/IJPRO2012-897412.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/0abae773468f/IJPRO2012-897412.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/b2c080c848c6/IJPRO2012-897412.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/2020eb0af0f8/IJPRO2012-897412.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/fe9efcc2a455/IJPRO2012-897412.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/304cdfe80efe/IJPRO2012-897412.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/dc4d4cf9c227/IJPRO2012-897412.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/0abae773468f/IJPRO2012-897412.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/b2c080c848c6/IJPRO2012-897412.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/2020eb0af0f8/IJPRO2012-897412.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/866c/3400370/fe9efcc2a455/IJPRO2012-897412.006.jpg

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Cancer Sci. 2011 Mar;102(3):630-8. doi: 10.1111/j.1349-7006.2010.01818.x. Epub 2010 Dec 28.
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