Ando Hitoshi, Fujimura Akio
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University.
Nihon Rinsho. 2012 Jul;70(7):1222-6.
Chronotherapy is defined as a coordination of biological rhythms with medical treatment. At present, several medications, including bronchodilating agents and H2 blockers, are administered with consideration for biological rhythms in routine clinical practice. In addition, recent studies have revealed that bedtime administration of antihypertensive medications can ameliorate the disturbed circadian rhythm of blood pressure and improve the prognosis in patients with hypertension. Because chronotherapy is a simple and inexpensive method of optimizing safe and effective pharmacotherapy, merits of this therapy should be evaluated in many medications.
时间治疗学被定义为生物节律与医学治疗的协调。目前，在常规临床实践中，包括支气管扩张剂和H2受体阻滞剂在内的几种药物的给药会考虑生物节律。此外，最近的研究表明，睡前服用抗高血压药物可以改善血压昼夜节律紊乱，并改善高血压患者的预后。由于时间治疗学是一种优化安全有效药物治疗的简单且廉价的方法，因此应该在许多药物中评估这种治疗方法的优点。
