Department of Biochemistry, University of Wisconsin-Madison, 1710 University Avenue, Madison, WI 53726, USA.
ACS Chem Biol. 2012 Sep 21;7(9):1477-81. doi: 10.1021/cb300323q. Epub 2012 Aug 27.
The importance of iron in living systems can be traced to the many complexes within which it is found, to its chemical mobility in undergoing oxidation-reduction reactions, and to the abundance of iron in Earth's crust. Iron is the most abundant element, by mass, in the Earth, constituting about 80% of the inner and outer cores of Earth. The molten outer core is about 8000 km in diameter, and the solid inner core is about 2400 km in diameter. Iron is the fourth most abundant element in Earth's crust. It is the chemically functional component of mononuclear iron complexes, dinuclear iron complexes, [2Fe-2S] and [4Fe-4S] clusters, [Fe-Ni-S] clusters, iron protophorphyrin IX, and many other complexes in protein biochemistry. Metals such as nickel, cobalt, copper, and manganese are present in the crust and could in principle function chemically in place of iron, but they are scarce in Earth's crust. Iron is plentiful because of its nuclear stability in stellar nuclear fusion reactions. It seems likely that other solid planets, formed by the same processes as Earth, would also foster the evolution of life and that iron would be similarly important to life on those planets as it is on Earth.
铁在生命体系中的重要性可以追溯到其存在的多种复合物、其在氧化还原反应中发生的化学迁移性以及铁在地壳中的丰富含量。铁是地球上最丰富的元素,其质量约占地球内外核的 80%。熔融的外核直径约为 8000 公里,而固体内核直径约为 2400 公里。铁是地壳中第四丰富的元素。它是单核铁复合物、双核铁复合物、[2Fe-2S]和[4Fe-4S]簇、[Fe-Ni-S]簇、铁原卟啉 IX 和蛋白质生物化学中许多其他复合物的化学功能组成部分。镍、钴、铜和锰等金属存在于地壳中,原则上可以在化学上替代铁,但它们在地壳中很稀缺。铁很丰富,因为它在恒星核聚变反应中的核稳定性。其他由与地球相同的过程形成的固体行星似乎也会促进生命的进化,而铁对这些行星上的生命的重要性与对地球上的生命的重要性相似。