Banciu T, Iova M, Biroaşiu G, Suşan L
4th Clinic of Internal Medicine, Institute of Medicine, Timişoara, Romania.
Med Interne. 1990 Jan-Mar;28(1):69-71.
The effect of nifedipine (10-20 mg) on esophageal motility was tested in 18 patients with clinical esophageal syndrome and radiologic aspect suggesting esophageal spasm. The drug was administered 20-30 min prior to the second radiologic examination. In 3 cases of achalasia the drug was administered in doses of 10 mg/day for 10 days before the second X-ray examination. Fiber esophagoscopy was performed in all the cases. The initial radiologic aspect was favourably influenced by nifedipine administration in 12 cases confirmed as esophageal spasm. The other 6 patients who did not benefit by the test were cases of organic diseases: 2 post caustic stenoses and 4 cases of eso-cardio-tuberal neoplasm. In the 3 cases of achalasia, treatment with nifedipine led to clinical improvement with relaxation of inferior esophageal contraction on radiologic examination. The study demonstrated the favourable contribution of calcium channel inhibitors to the diagnosis and treatment of esophageal motility disturbances.
对18例有临床食管综合征且放射学表现提示食管痉挛的患者，测试了硝苯地平（10 - 20毫克）对食管动力的影响。在第二次放射学检查前20 - 30分钟给药。对于3例贲门失弛缓症患者，在第二次X线检查前10天给予10毫克/天的剂量，持续10天。所有病例均进行了纤维食管镜检查。在确诊为食管痉挛的12例患者中，硝苯地平给药对初始放射学表现有有利影响。另外6例未从该试验中获益的患者为器质性疾病：2例腐蚀性狭窄后病例和4例食管 - 心 - 结节性肿瘤病例。在3例贲门失弛缓症患者中，硝苯地平治疗使临床症状改善，放射学检查显示食管下段收缩松弛。该研究证明了钙通道抑制剂对食管动力障碍的诊断和治疗有有利作用。
