Department of Chemistry, UGC Sponsored-Centre of Advance Studies-1, Guru Nanak Dev University, Amritsar, India.
Langmuir. 2012 Aug 21;28(33):11969-78. doi: 10.1021/la300920p. Epub 2012 Aug 10.
New gemini imidazolium surfactants 9-13 have been synthesized by a regioselective epoxy ring-opening reaction under solvent-free conditions. The surface properties of these new gemini surfactants were evaluated by surface tension and conductivity measurements. These surfactants have been found to have low critical micelle concentration (cmc) values as compared to other categories of gemini cationic surfactants and also showed the tendency to form premicellar aggregates in solution at sufficiently low concentration below their cmc values. The thermal degradation of these surfactants was determined by thermograviometry analysis (TGA). These new cationic surfactants have a good DNA binding capability as determined by agarose gel electrophoresis and ethidium bromide exclusion experiments. They have also been found to have low cytotoxicity by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on the C6 glioma cell line.
新的双子咪唑啉表面活性剂 9-13 通过无溶剂条件下的区域选择性环氧开环反应合成。通过表面张力和电导率测量评估了这些新双子表面活性剂的表面性质。与其他类型的双子阳离子表面活性剂相比，这些表面活性剂具有较低的临界胶束浓度 (cmc) 值，并且在低于其 cmc 值的足够低浓度下在溶液中也表现出形成预胶束聚集的趋势。通过热重分析 (TGA) 确定这些表面活性剂的热降解。通过琼脂糖凝胶电泳和溴化乙锭排除实验确定这些新的阳离子表面活性剂具有良好的 DNA 结合能力。通过 C6 神经胶质瘤细胞系的 MTT（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴化物）测定，它们也被发现具有低细胞毒性。
