Department of Neurology and Neuroscience, Weill Cornell Medical College/New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10065‐4885, USA.
J Neurol Sci. 2012 Oct 15;321(1-2):35-8. doi: 10.1016/j.jns.2012.07.028. Epub 2012 Jul 29.
Two patients with recurrent lymphoma developed an acute, transient encephalopathy following administration of recombinant human granulocyte-colony stimulating factor (rhG-CSF), filgrastim, in anticipation of leukapheresis for hematopoietic stem cell transplantation. Head magnetic resonance imaging showed evidence of blood-brain barrier (BBB) breakdown, compatible with posterior reversible encephalopathy syndrome (PRES). The proposed pathogenesis of PRES was rhG-CSF-induced neutrophil mobilization and activation with the release of inflammatory mediators, resulting in transient alteration of barrier permeability and capillary leakage.
两位复发性淋巴瘤患者在接受重组人粒细胞集落刺激因子（rhG-CSF）、非格司亭预期性白细胞分离术以进行造血干细胞移植后出现急性短暂性脑病。头部磁共振成像显示血脑屏障（BBB）破裂的证据，符合后部可逆性脑病综合征（PRES）。 PRES 的发病机制可能是 rhG-CSF 诱导中性粒细胞动员和激活，释放炎症介质，导致屏障通透性和毛细血管渗漏的短暂改变。
