Kidney Int. 2012 Aug;82(4):375-7. doi: 10.1038/ki.2012.152.
Horizontal information transfer between cells via microparticles is a newly identified communication system. MicroRNAs regulate gene expression and are detected in microparticles. Cantaluppi et al. suggest that microparticles derived from circulating angiogenic cells--'endothelial progenitor cells' (EPCs)--harbor endothelial-protective miRNAs such as miR-126 and that delivery of EPC-derived microparticles during acute kidney ischemia-reperfusion in rats ameliorates kidney dysfunction and damage. We highlight the importance, potential future impact, and limitations of this study.
细胞间通过微粒进行水平信息传递是一种新发现的通讯系统。microRNAs 调节基因表达,并存在于微粒中。Cantaluppi 等人提出,来源于循环血管生成细胞(“内皮祖细胞”(EPCs))的微粒携带内皮保护 microRNAs,如 miR-126,并且在大鼠急性肾缺血再灌注期间给予 EPC 衍生的微粒可改善肾功能障碍和损伤。我们强调了这项研究的重要性、潜在的未来影响和局限性。