Salybekov Amankeldi A, Kunikeyev Aidyn D, Kobayashi Shuzo, Asahara Takayuki
Division of Regenerative Medicine, Department of Center for Clinical and Translational Science, Shonan Kamakura General Hospital, Kamakura, Japan.
Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura, Japan.
Front Cardiovasc Med. 2021 Oct 4;8:734562. doi: 10.3389/fcvm.2021.734562. eCollection 2021.
Almost all nucleated cells secrete extracellular vesicles (EVs) that are heterogeneous spheroid patterned or round shape particles ranging from 30 to 200 nm in size. Recent preclinical and clinical studies have shown that endothelial progenitor cell-derived EVs (EPC-EVs) have a beneficial therapeutic effect in various diseases, including cardiovascular diseases and kidney, and lung disorders. Moreover, some animal studies have shown that EPC-EVs selectively accumulate at the injury site with a specific mechanism of binding along with angiogenic and restorative effects that are superior to those of their ancestors. This review article highlights current advances in the biogenesis, delivery route, and long-term storage methods of EPC-EVs and their favorable effects such as anti-inflammatory, angiogenic, and tissue protection in various diseases. Finally, we review the possibility of therapeutic application of EPC-EVs in the clinic.
几乎所有有核细胞都会分泌细胞外囊泡（EVs），这些囊泡是大小在30到200纳米之间的异质球状或圆形颗粒。最近的临床前和临床研究表明，内皮祖细胞衍生的细胞外囊泡（EPC-EVs）在包括心血管疾病、肾脏疾病和肺部疾病在内的各种疾病中具有有益的治疗作用。此外，一些动物研究表明，EPC-EVs通过特定的结合机制选择性地聚集在损伤部位，其血管生成和修复作用优于其前体细胞。本文综述了EPC-EVs的生物发生、递送途径、长期储存方法的当前进展，以及它们在各种疾病中的抗炎、血管生成和组织保护等有益作用。最后，我们回顾了EPC-EVs在临床上治疗应用的可能性。
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