Gao Jie, Liu Qing-Guang
Hepatobiliary Surgery Department, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Yanta Road 277, Xi'an, Shaanxi 710061, P.R. China.
Oncol Lett. 2011 Nov;2(6):1019-1023. doi: 10.3892/ol.2011.413. Epub 2011 Sep 5.
miR-26, a functional miRNA, has received much attention from researchers in recent years. miRNAs may play crucial roles in numerous biological processes such as cell proliferation, apoptosis, tumorigenesis at different stages of non-tumor diseases, growth and development of normal tissues, and other biological processes. The expression of miR-26 has been found to be specific to different biological processes. Furthermore, its expression is frequently abnormal in tumors, indicating that miR-26 may play significant roles in tumor formation. Various reports exist regarding miR-26 involvement in non-tumor diseases, as well as the process of growth and development of normal tissues. In this review, we report findings of recent studies on the expression of miR-26 in different types of diseases and the process of growth and development and its predicted target genes in different tissue types. In conclusion, it is useful for researchers to understand the role of miR-26 in different biological processes.
miR-26是一种功能性微小RNA（miRNA），近年来受到了研究人员的广泛关注。微小RNA可能在众多生物学过程中发挥关键作用，如细胞增殖、凋亡、非肿瘤性疾病不同阶段的肿瘤发生、正常组织的生长和发育以及其他生物学过程。已发现miR-26的表达在不同生物学过程中具有特异性。此外，其表达在肿瘤中经常异常，表明miR-26可能在肿瘤形成中发挥重要作用。关于miR-26参与非肿瘤性疾病以及正常组织生长和发育过程，已有各种报道。在本综述中，我们报告了近期关于miR-26在不同类型疾病中的表达、生长和发育过程及其在不同组织类型中的预测靶基因的研究结果。总之，了解miR-26在不同生物学过程中的作用对研究人员很有帮助。
