台湾地区一项病例对照研究显示：植物性维生素、鲜鱼、绿茶和咖啡摄入降低鼻咽癌风险。
Lowered risk of nasopharyngeal carcinoma and intake of plant vitamin, fresh fish, green tea and coffee: a case-control study in Taiwan.
机构信息
Genomics Research Center, Academia Sinica, Taipei, Taiwan.
出版信息
PLoS One. 2012;7(7):e41779. doi: 10.1371/journal.pone.0041779. Epub 2012 Jul 27.
BACKGROUND
A case-control study was conducted to evaluate the role of adult diet on nasopharyngeal carcinoma (NPC) in Taiwan.
METHODS
A total of 375 incident NPC cases and 327 controls matched to the cases on sex, age, and residence were recruited between July 1991 and December 1994. A structured questionnaire inquiring complete dietary history, socio-demographic characteristics, and other potential confounding factors was used in the personal interview. Unconditional logistic regression analysis was used to estimate multivariate-adjusted odds ratio (OR(adj)) with 95% confidence interval (CI) after accounting for known risk factors.
RESULTS
Fresh fish (OR(adj), 0.56; 95% CI, 0.38-0.83 for the highest vs. lowest tertile of intake), green tea (OR(adj), 0.61; 95% CI, 0.40-0.91 for drinking ≥1 times/week vs. never) and coffee (OR(adj), 0.56; 95% CI, 0.37-0.85 for drinking ≥0.5 times/week vs. never) were inversely associated with the NPC risk. No association with NPC risk was observed for the intake of meats, salted fish, fresh vegetables, fruits and milk. Intake of vitamin A from plant sources was associated with a decreased NPC risk (OR(adj), 0.62; 95% CI, 0.41-0.94 for the highest vs. lowest tertile).
CONCLUSION
The study findings suggest that certain adult dietary patterns might protect against the development of NPC.
背景
本病例对照研究旨在评估成人饮食在台湾地区鼻咽癌（NPC）发病中的作用。
方法
1991 年 7 月至 1994 年 12 月期间，共招募了 375 例 NPC 新发病例和 327 例性别、年龄和居住地匹配的对照。通过个人访谈，使用一份结构式问卷，调查了完整的饮食史、社会人口统计学特征和其他潜在的混杂因素。在考虑已知危险因素后，采用非条件 logistic 回归分析，估计了多变量调整后的比值比（OR(adj)）及其 95%置信区间（CI）。
结果
与摄入最低三分位相比，摄入较高水平的新鲜鱼类（OR(adj)，0.56；95%CI，0.38-0.83）、绿茶（OR(adj)，0.61；95%CI，0.40-0.91）和咖啡（OR(adj)，0.56；95%CI，0.37-0.85）与 NPC 发病风险呈负相关。而摄入肉类、咸鱼、新鲜蔬菜、水果和牛奶与 NPC 发病风险无显著相关性。植物来源的维生素 A 摄入与 NPC 发病风险降低相关（OR(adj)，0.62；95%CI，0.41-0.94）。
结论
本研究结果提示某些成人饮食模式可能有助于预防 NPC 的发生。
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