Lo Yen-Li, Pan Wen-Harn, Hsu Wan-Lun, Chien Yin-Chu, Chen Jen-Yang, Hsu Mow-Ming, Lou Pei-Jen, Chen I-How, Hildesheim Allan, Chen Chien-Jen
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Genomics Research Center, Academia Sinica, Taipei, Taiwan.
PLoS One. 2016 Jun 1;11(6):e0155892. doi: 10.1371/journal.pone.0155892. eCollection 2016.
Evidence on the association between dietary component, dietary pattern and nasopharyngeal carcinoma (NPC) is scarce. A major challenge is the high degree of correlation among dietary constituents. We aimed to identify dietary pattern associated with NPC and to illustrate the dose-response relationship between the identified dietary pattern scores and the risk of NPC. Taking advantage of a matched NPC case-control study, data from a total of 319 incident cases and 319 matched controls were analyzed. Dietary pattern was derived employing partial least square discriminant analysis (PLS-DA) performed on energy-adjusted food frequencies derived from a 66-item food-frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with multiple conditional logistic regression models, linking pattern scores and NPC risk. A high score of the PLS-DA derived pattern was characterized by high intakes of fruits, milk, fresh fish, vegetables, tea, and eggs ordered by loading values. We observed that one unit increase in the scores was associated with a significantly lower risk of NPC (ORadj = 0.73, 95% CI = 0.60-0.88) after controlling for potential confounders. Similar results were observed among Epstein-Barr virus seropositive subjects. An NPC protective diet is indicated with more phytonutrient-rich plant foods (fruits, vegetables), milk, other protein-rich foods (in particular fresh fish and eggs), and tea. This information may be used to design potential dietary regimen for NPC prevention.
关于饮食成分、饮食模式与鼻咽癌（NPC）之间关联的证据稀少。一个主要挑战是饮食成分之间的高度相关性。我们旨在确定与鼻咽癌相关的饮食模式，并阐明所确定的饮食模式得分与鼻咽癌风险之间的剂量反应关系。利用一项匹配的鼻咽癌病例对照研究，分析了总共319例新发病例和319例匹配对照的数据。饮食模式采用偏最小二乘判别分析（PLS - DA）得出，该分析基于一份66项食物频率问卷得出的能量调整后的食物频率进行。通过多条件逻辑回归模型估计优势比（OR）和95%置信区间（CI），将模式得分与鼻咽癌风险联系起来。PLS - DA得出的模式高分的特征是按载荷值排序的水果、牛奶、鲜鱼、蔬菜、茶和鸡蛋的高摄入量。在控制潜在混杂因素后，我们观察到得分每增加一个单位与鼻咽癌风险显著降低相关（调整后的OR = 0.73，95% CI = 0.60 - 0.88）。在爱泼斯坦 - 巴尔病毒血清阳性受试者中也观察到了类似结果。一种富含植物营养素（水果、蔬菜）、牛奶、其他富含蛋白质的食物（特别是鲜鱼和鸡蛋）以及茶的鼻咽癌保护性饮食被指出。这些信息可用于设计预防鼻咽癌的潜在饮食方案。
