Tetsuo M, Hamada T, Yoshimatsu K, Ishimatsu J, Matsunaga T
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan.
Acta Obstet Gynecol Scand. 1990;69(6):479-85. doi: 10.3109/00016349009013322.
In 25 normally non-pregnant women, 543 normally pregnant women and 75 pregnant women with diabetes mellitus or gestational diabetes mellitus, the relationship between the serum concentration of 1,5-anhydro-D-glucitol (1-deoxy-glucose) and carbohydrate metabolism was studied. The concentration of 1,5-anhydro-D-glucitol was estimated by means of gas-liquid chromatography. In normally non-pregnant women the concentration was found to be 18.6 +/- 5.2 mg/l (mean +/- SD). During the normal pregnancy, from 9 weeks of gestation, a steadily decreasing concentration was observed as the pregnancy progressed and the lowest value (10.2 +/- 4.6 mg/l) was found in the third trimester. After 5 days of puerperium the concentrations were found to be 10.8 +/- 3.7 mg/l. On the 30th day postpartum, the level was within the range for non-pregnant subjects. The values in pregnant women with diabetes mellitus and gestational diabetes mellitus were mostly below 10 mg/l throughout the entire pregnant period. The 1,5-anhydro-D-glucitol concentration was not affected by meals or oral glucose loading. A concentration below 10 mg/l was found in 36% of the normally pregnant women, where oral glucose tolerance tests and measurement of glycohemoglobin were shown to be within the normal range. The present study suggests that a change of 1,5-anhydro-D-glucitol level during pregnancy may reflect a mild alteration of carbohydrate metabolism that goes undetected by all the other diabetic indicators.
在25名正常非妊娠妇女、543名正常妊娠妇女以及75名患有糖尿病或妊娠期糖尿病的妊娠妇女中，研究了1,5 - 脱水 - D - 葡萄糖醇（1 - 脱氧葡萄糖）的血清浓度与碳水化合物代谢之间的关系。1,5 - 脱水 - D - 葡萄糖醇的浓度通过气液色谱法进行测定。在正常非妊娠妇女中，该浓度为18.6±5.2mg/l（平均值±标准差）。在正常妊娠期间，从妊娠9周开始，随着妊娠进展观察到浓度持续下降，在妊娠晚期发现最低值（10.2±4.6mg/l）。产后5天时，浓度为10.8±3.7mg/l。产后第30天，该水平处于非妊娠受试者的范围内。患有糖尿病和妊娠期糖尿病的妊娠妇女在整个孕期的数值大多低于10mg/l。1,5 - 脱水 - D - 葡萄糖醇浓度不受进餐或口服葡萄糖负荷的影响。在36%的正常妊娠妇女中发现浓度低于10mg/l，而这些妇女的口服葡萄糖耐量试验和糖化血红蛋白测量结果显示在正常范围内。本研究表明，孕期1,5 - 脱水 - D - 葡萄糖醇水平的变化可能反映了碳水化合物代谢的轻度改变，而这种改变通过所有其他糖尿病指标均未被检测到。
