Sauer M V, Paulson R J, Chenette P, Frederick J, Stanczyk F Z
Department of Obstetrics and Gynecology, University of Southern California, Los Angeles.
Gynecol Endocrinol. 1990 Sep;4(3):145-9. doi: 10.3109/09513599009009801.
To determine the effect hydration has upon the relationship between serum progesterone and its urinary metabolite pregnanediol-3 alpha-glucuronide (PDG) we measured spot samples from patients (n = 207) presenting in the 1st trimester of pregnancy. Serum and urine specimens were obtained simultaneously and measured for progesterone and PDG by radioimmunoassay (RIA). Urine specific gravity was also measured at the time of sample collection. Results demonstrated that in samples where the urine specific gravity was greater than or equal to 1.015 there was a strong positive correlation between serum progesterone and PDG (r greater than 0.60, p less than 0.001). However, when urine samples were below a specific gravity of 1.015, serum and urinary steroid values correlated poorly or not at all. We conclude that the measurement of specific gravity should be routinely performed when determining random values of urinary PDG, since only samples in which the urine is adequately concentrated accurately reflect corresponding serum progesterone concentrations.
为了确定水合作用对血清孕酮与其尿代谢产物孕二醇 - 3α - 葡萄糖醛酸苷（PDG）之间关系的影响，我们对妊娠早期就诊的患者（n = 207）的即时样本进行了测量。同时采集血清和尿液样本，并通过放射免疫分析（RIA）测定孕酮和PDG。在采集样本时还测量了尿比重。结果表明，在尿比重≥1.015的样本中，血清孕酮与PDG之间存在强正相关（r＞0.60，p＜0.001）。然而，当尿液样本比重低于1.015时，血清和尿类固醇值相关性差或根本无相关性。我们得出结论，在测定尿PDG随机值时应常规测量比重，因为只有尿液充分浓缩的样本才能准确反映相应的血清孕酮浓度。
