Frederick J L, Chenette P E, Paulson R J, Stanczyk F Z, Sauer M V
Department of Obstetrics and Gynecology, University of Southern California, Los Angeles.
Hum Reprod. 1990 May;5(4):468-70. doi: 10.1093/oxfordjournals.humrep.a137125.
Progesterone and its urinary metabolite pregnanediol-3 alpha-glucuronide (PDG) are generally lower in women with abnormal pregnancies compared to those with normal intrauterine gestations. We evaluated the ability of random urinary PDG measurements determined by enzyme immunoassay (EIA) to differentiate normal from abnormal pregnancies. Patients with first-trimester vaginal bleeding (n = 104) were evaluated. Eventual outcomes indicated 39 women had viable intrauterine pregnancies (IUPs), 54 had spontaneous abortions (SABs) and 11 had ectopic pregnancies (EPs). Urinary PDG was significantly lower in SAB and EP compared to IUP patients. However, a wide range of values in IUP patients was noted (3.2-93.3 micrograms/ml), due to varying degrees of patient hydration at presentation. Hence, random measures of urinary PDG demonstrated poor specificity (32.8%) in correctly differentiating normal from abnormal gestations, thus limiting its clinical usefulness.
与正常宫内妊娠的女性相比，异常妊娠女性体内的孕酮及其尿液代谢产物孕二醇 - 3α - 葡萄糖醛酸苷（PDG）水平通常较低。我们评估了通过酶免疫测定法（EIA）测定随机尿样中PDG来区分正常妊娠与异常妊娠的能力。对孕早期阴道出血的患者（n = 104）进行了评估。最终结果显示，39名女性有存活的宫内妊娠（IUP），54名发生自然流产（SAB），11名有异位妊娠（EP）。与IUP患者相比，SAB和EP患者的尿PDG水平显著降低。然而，由于就诊时患者的水化程度不同，IUP患者的PDG值范围较宽（3.2 - 93.3微克/毫升）。因此，随机测定尿PDG在正确区分正常妊娠与异常妊娠方面特异性较差（32.8%），从而限制了其临床应用价值。
