Sauer M V, Vermesh M, Anderson R E, Vijod A G, Stanczyk F Z, Lobo R A
Division of Reproductive Endocrinology, University of Southern California, Los Angeles.
Am J Obstet Gynecol. 1988 Dec;159(6):1531-5. doi: 10.1016/0002-9378(88)90589-3.
We investigated the ability of a single, random, urinary pregnanediol-3 alpha-glucuronide level to differentiate early intrauterine from ectopic pregnancy. Thirty-four patients with intrauterine gestations were compared with 60 patients with ectopic pregnancies. Urinary pregnanediol-3 alpha-glucuronide was measured by radioimmunoassay and enzyme immunoassay. Compared with intrauterine gestations, results demonstrate that urinary pregnanediol-3 alpha-glucuronide is significantly depressed in ectopic pregnancies: 24.5 +/- 2.2 versus 4.8 +/- 0.7 micrograms/ml (p = 0.0001). Urinary pregnanediol-3 alpha-glucuronide levels obtained by conventional radioimmunoassay correlated closely with values measured in minutes with enzyme immunoassay (r = 0.95, p = 0.0001), and with serum progesterone (r = 0.74, p = 0.0001). Urinary pregnanediol-3 alpha-glucuronide measured by enzyme immunoassay exhibited predictive values for detecting ectopic gestations comparable with random serum progesterone or serum beta-human chorionic gonadotropin values. We conclude that ectopic gestations demonstrate a reduced level of urinary pregnanediol-3 alpha-glucuronide (55/60 cases) detectable with a rapid enzyme immunoassay, which makes this assay a practical screening test in early pregnancy.
我们研究了单次随机尿孕二醇-3α-葡萄糖醛酸苷水平区分早期宫内妊娠与异位妊娠的能力。将34例宫内妊娠患者与60例异位妊娠患者进行比较。通过放射免疫测定法和酶免疫测定法测量尿孕二醇-3α-葡萄糖醛酸苷。与宫内妊娠相比，结果表明异位妊娠时尿孕二醇-3α-葡萄糖醛酸苷显著降低：分别为24.5±2.2与4.8±0.7微克/毫升（p = 0.0001）。通过传统放射免疫测定法获得的尿孕二醇-3α-葡萄糖醛酸苷水平与酶免疫测定法在数分钟内测得的值密切相关（r = 0.95，p = 0.0001），且与血清孕酮相关（r = 0.74，p = 0.0001）。通过酶免疫测定法测量的尿孕二醇-3α-葡萄糖醛酸苷对检测异位妊娠的预测价值与随机血清孕酮或血清β-人绒毛膜促性腺激素值相当。我们得出结论，异位妊娠表现出尿孕二醇-3α-葡萄糖醛酸苷水平降低（60例中有55例），可通过快速酶免疫测定法检测到，这使得该测定法成为早期妊娠实用的筛查试验。
