Unnikrishnan M K, Rao M N
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Agents Actions. 1990 Aug;31(1-2):110-2. doi: 10.1007/BF02003229.
The oxidation of methionine in peptides is often associated with the loss of biological activity. Since methionine showed good antiinflammatory activity, its oxidized products methionine sulfoxide and methionine sulfone were tested. The sulfone was more active than the sulfoxide although methionine was most active indicating that the antiinflammatory activity is not correlated with the oxidation state of sulphur. Their hydroxyl radical scavenging activity was measured. Methionine was most active and sulfone was least active. Here also no correlation with antiinflammatory activity was found.
肽中蛋氨酸的氧化常常与生物活性的丧失有关。由于蛋氨酸具有良好的抗炎活性，因此对其氧化产物甲硫氨酸亚砜和甲砜进行了测试。尽管蛋氨酸活性最高，但砜比亚砜更具活性，这表明抗炎活性与硫的氧化态无关。测定了它们的羟基自由基清除活性。蛋氨酸活性最高，砜活性最低。在这方面也未发现与抗炎活性相关。
