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肌酸抗炎活性的研究。

Studies on the anti-inflammatory activity of creatine.

作者信息

Khanna N K, Madan B R

出版信息

Arch Int Pharmacodyn Ther. 1978 Feb;231(2):340-50.

PMID:646528
Abstract

Creatine is an aminoacid which has been found to posses anti-inflammatory activity. It is orally effective in modifying the inflammatory response in all of the test models employed. It does not produce gastrointestinal ulceration in the effective doses. In common with many of the nonsteroidal anti-inflammatory agents creatin exhibits analgesic activity. Anti-inflammatory activity is comparable to that of phenylbutazone and merits further studies.

摘要

肌酸是一种已被发现具有抗炎活性的氨基酸。在所有使用的测试模型中,它口服后能有效调节炎症反应。在有效剂量下它不会导致胃肠道溃疡。与许多非甾体抗炎药一样,肌酸具有镇痛活性。其抗炎活性与保泰松相当,值得进一步研究。

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2
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引用本文的文献

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Front Vet Sci. 2022 Nov 25;9:1063169. doi: 10.3389/fvets.2022.1063169. eCollection 2022.
2
Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment.通过 GATM 介导的内源性肌酸合成重编程替代型巨噬细胞极化:一种潜在的 HDM 诱导哮喘治疗靶点。
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Cells. 2021 Oct 27;10(11):2902. doi: 10.3390/cells10112902.
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The Role of Creatine in the Development and Activation of Immune Responses.肌酸在免疫应答的发展和激活中的作用。
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The Evolving Applications of Creatine Supplementation: Could Creatine Improve Vascular Health?肌酸补充剂的应用进展:肌酸能改善血管健康吗?
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Effects of various dietary supplements on inflammatory processes in primary canine chondrocytes as a model of osteoarthritis.以原代犬软骨细胞作为骨关节炎模型,研究各种膳食补充剂对炎症过程的影响。
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