Department of Developmental Physiology & Nutrition, Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands.
Pediatr Res. 2012 Oct;72(4):362-9. doi: 10.1038/pr.2012.101. Epub 2012 Jul 31.
In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming. We developed a concept infant formula (IMF) with large, phospholipid-coated lipid droplets (Nuturis; Danone Research, Paris, France) and investigated its programming effect on metabolic phenotype later in life.
Male C57Bl/6j mice were fed a control formula (Control IMF) or Nuturis (Concept IMF) diet between postnatal day (PN)16 and PN42. All mice were subsequently fed a Western-style diet (WSD) until PN126. Body composition was monitored repeatedly by dual-energy X-ray absorptiometry between PN42 and PN126.
Concept IMF slightly increased lean body mass as compared with Control IMF at PN42 but did not affect fat mass. Upon 84 d of WSD feeding, the Concept IMF group showed reduced fat accumulation as compared with Control IMF. In addition, fasting plasma leptin, resistin, glucose, and lipids were significantly lower in the Concept IMF group.
Large phospholipid-coated lipid droplets in young mice reduced fat accumulation and improved metabolic profile in adulthood. These data emphasize that physical properties of early dietary lipids contribute to metabolic programming.
除了导致全球肥胖患病率增加的当代生活方式因素外，早期营养与肥胖持续到以后生活的效应有关。我们假设膳食脂质的物理特性有助于这种营养编程。我们开发了一种概念婴儿配方（IMF），其中含有大的、磷脂包裹的脂滴（Nuturis；Danone Research，巴黎，法国），并研究了其对以后生活中代谢表型的编程作用。
雄性 C57Bl/6j 小鼠在出生后第 16 天至第 42 天期间分别喂食对照配方（Control IMF）或 Nuturis（Concept IMF）饮食。所有小鼠随后均喂食西式饮食（WSD）至第 126 天。通过双能 X 射线吸收法在第 42 天至第 126 天之间反复监测身体成分。
与 Control IMF 相比，Concept IMF 在第 42 天略微增加了瘦体重，但不影响脂肪量。在 WSD 喂养 84 天后，与 Control IMF 相比，Concept IMF 组的脂肪积累减少。此外，Concept IMF 组的空腹血浆瘦素、抵抗素、血糖和脂质明显降低。
年幼小鼠中较大的磷脂包裹的脂滴减少了脂肪积累，并改善了成年后的代谢特征。这些数据强调了早期膳食脂质的物理特性有助于代谢编程。
