Ellaurie M, Burns E R, Rubinstein A
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
Am J Pediatr Hematol Oncol. 1990 Winter;12(4):449-53. doi: 10.1097/00043426-199024000-00008.
The hematologic profile of 100 symptomatic children infected by the human immunodeficiency virus (HIV) was evaluated and compared to HIV uninfected infants with transplacentally acquired maternal anti-HIV antibodies, and to HIV-negative infants born to i.v. drug-abusing HIV uninfected mothers. Anemia was present in 94% of HIV-infected infants and was a major predictor of disease progression. In 91% of patients having a hematocrit (HcT) less than 25%, the disease course was rapidly fatal. Leukopenia and thrombocytopenia occurred in 47 and 33% of HIV infected patients, respectively. Neutropenia was most severe in children with opportunistic infections. There was no evidence of suppression of any component of hematopoiesis by passively acquired antibodies to HIV.
对100名感染人类免疫缺陷病毒（HIV）的有症状儿童的血液学特征进行了评估，并与通过胎盘获得母体抗HIV抗体的未感染HIV的婴儿以及静脉注射吸毒的未感染HIV母亲所生的HIV阴性婴儿进行了比较。94%的HIV感染婴儿存在贫血，且贫血是疾病进展的主要预测指标。在血细胞比容（HcT）低于25%的患者中，91%的病程迅速致命。47%和33%的HIV感染患者分别出现白细胞减少和血小板减少。中性粒细胞减少在机会性感染儿童中最为严重。没有证据表明被动获得的抗HIV抗体对造血的任何成分有抑制作用。
