Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Magn Reson Med. 2012 Oct;68(4):1262-5. doi: 10.1002/mrm.24430. Epub 2012 Jul 31.
Nuclear spin hyperpolarization makes a significant advance toward overcoming the sensitivity limitations of in vivo magnetic resonance imaging, particularly in the case of low-gamma nuclei. The sensitivity may be improved further by storing the hyperpolarization in slowly relaxing singlet populations of spin-1/2 pairs. Here, we report hyperpolarized (13) C spin order transferred into and retrieved from singlet spin order using a small animal magnetic resonance imaging scanner. For spins in sites with very similar chemical shifts, singlet spin order is sustained in high magnetic field without requiring strong radiofrequency irradiation. The demonstration of robust singlet-to-magnetization conversion, and vice versa, on a small animal scanner, is promising for future in vivo and clinical deployments.
核自旋超极化技术在克服活体磁共振成像的灵敏度限制方面取得了重大进展，特别是对于低γ核。通过将超极化存储在自旋-1/2 对的缓慢弛豫单重态群体中，可以进一步提高灵敏度。在这里，我们使用小动物磁共振成像扫描仪报告了（13）C 自旋顺序通过单重态自旋顺序转移到和从中检索的过程。对于化学位移非常相似的部位中的自旋，在高磁场中单重态自旋顺序得以维持，而无需强射频辐射。在小动物扫描仪上对稳健的单重态到磁化转换的演示，以及反之亦然，为未来的体内和临床应用提供了希望。
