Okada T, Morikawa Y
Department of Veterinary Anatomy, College of Agriculture, University of Osaka Prefecture, Japan.
Anat Rec. 1990 Dec;228(4):456-60. doi: 10.1002/ar.1092280412.
Development of the proximal tubule in the fetal kidney was studied following ligation of both ureters of pregnant rats. The ligation was performed on days 15, 17, 19, and 21 of gestation and autopsy followed 24 hours after each operation. On fetal days 20 and 22, the proximal tubular length per unit volume (1 mm3) of whole kidney of the fetuses from the ligated mothers was significantly increased, while the ratio of total glomerular volume to total proximal tubular volume was remarkably decreased when compared to that of the fetuses from the non-ligated mothers. Apical vacuoles in proximal tubular cells were increased by the ligation on fetal days 20 and 22. These findings suggest that maternal bilateral ureteral ligation accelerates the growth and differentiation of the proximal tubule in fetal kidney, when the fetal kidney is functional in urine production.
通过结扎怀孕大鼠的双侧输尿管，研究了胎儿肾脏近端小管的发育情况。在妊娠第15、17、19和21天进行结扎，并在每次手术后24小时进行尸检。在胎儿第20和22天，与未结扎母亲的胎儿相比，结扎母亲的胎儿全肾每单位体积（1立方毫米）的近端小管长度显著增加，而肾小球总体积与近端小管总体积的比值显著降低。胎儿第20和22天的结扎使近端小管细胞的顶端空泡增加。这些发现表明，当胎儿肾脏具有尿液生成功能时，母体双侧输尿管结扎会加速胎儿肾脏近端小管的生长和分化。
