Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehak-ro, Jongro-gu, Seoul 110-799, Republic of Korea.
Hypertension. 2012 Sep;60(3):786-93. doi: 10.1161/HYPERTENSIONAHA.112.197715. Epub 2012 Jul 30.
Bisphenol A (BPA) is a high-volume production chemical that has been suspected to have adverse health effects. Recent studies have suggested that cardiovascular diseases are associated with the BPA exposure. The aim of present study was to investigate the associations of urinary BPA with heart rate variability and blood pressure. We recruited 560 noninstitutionalized elderly citizens from August 2008 to August 2010 in Seoul. All of the participants were ≥60 years old. The participants took medical examinations ≤5 times. Urinary BPA concentration, heart rate variability, and blood pressure were measured at each time. A total of 1511 observations from 521 participants were included in the analyses. We observed that urinary BPA was associated negatively with the root mean square of successive differences for heart rate and positively with blood pressure. The odds ratio of showing hypertension (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg) was 1.27 (95% CI, 0.85-1.88) in the fourth quartile compared with the first quartile of urinary BPA concentration. When the analyses were restricted to participants who did not report previous history of hypertension (n=258), the odds ratio was increased to 2.35 (95% CI, 1.33-4.17).
双酚 A（BPA）是一种高产量的化学物质，其对健康的不良影响一直受到怀疑。最近的研究表明，心血管疾病与 BPA 暴露有关。本研究旨在探讨尿液中 BPA 与心率变异性和血压的关系。我们于 2008 年 8 月至 2010 年 8 月在首尔招募了 560 名非住院的老年市民。所有参与者年龄均≥60 岁。参与者在≤5 次的体检中接受了检查。在每次体检时，我们测量了尿液中 BPA 浓度、心率变异性和血压。共有 521 名参与者的 1511 次观察结果纳入了分析。我们发现，尿液中 BPA 与心率的连续差值的均方根呈负相关，与血压呈正相关。与尿液中 BPA 浓度第一四分位数相比，第四四分位数患高血压（收缩压≥140mmHg 或舒张压≥90mmHg）的比值比为 1.27（95%CI，0.85-1.88）。当将分析限制在未报告既往高血压病史的参与者（n=258）中时，比值比增加到 2.35（95%CI，1.33-4.17）。
