Shakya D R, Dutta A, Gautam R
Department of Psychiatry, B. P. Koirala Institute of Health Sciences, 56700 Dharan, Nepal.
Case Rep Med. 2012;2012:706243. doi: 10.1155/2012/706243. Epub 2012 Jul 19.
Levetiracetam, a relatively new antiepileptic drug (AED), is used mainly as adjuvant and less as monotherapy of seizure. Though rare, Levetiracetam is reported to induce hallucination. To highlight the potential of this adverse drug event, we report a seizure-case that had auditory hallucination with Levetiracetam. A 32-year lady had 7-year history of unresponsive spells which increased in the last year, also occurred while asleep and were diagnosed as "generalized seizure" with video-EEG. With gradual optimization of Levetiracetam to 2250 mg, she continuously heard distressing sound of saw cutting wooden blocks. After 3-day continuous auditory hallucination, Levetiracetam had to be changed to sodium valproate.
左乙拉西坦是一种相对较新的抗癫痫药物（AED），主要用作辅助治疗，较少用于癫痫发作的单药治疗。尽管罕见，但有报道称左乙拉西坦可诱发幻觉。为了突出这种药物不良事件的可能性，我们报告一例使用左乙拉西坦后出现幻听的癫痫病例。一名32岁女性有7年无反应发作史，去年发作次数增加，睡眠时也会发作，经视频脑电图诊断为“全身性癫痫发作”。随着左乙拉西坦逐渐增至2250毫克，她持续听到锯木块的痛苦声音。持续幻听3天后，不得不将左乙拉西坦换成丙戊酸钠。
