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Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation.正在接受口服或静脉制剂治疗的伤寒热患者血清中的氯霉素浓度。
Antimicrob Agents Chemother. 1990 Sep;34(9):1809-11. doi: 10.1128/AAC.34.9.1809.
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Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections.侵袭性沙门氏菌感染的流行病学、临床表现、实验室诊断、抗菌药物耐药性及抗菌药物管理
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本文引用的文献

1
Simultaneous measurement of chloramphenicol and chloramphenicol succinate by high-performance liquid chromatography.高效液相色谱法同时测定氯霉素和琥珀氯霉素
J Chromatogr. 1980 Nov 14;221(1):176-81. doi: 10.1016/s0378-4347(00)81022-1.
2
Chloramphenicol sodium succinate kinetics in critically ill patients.危重症患者中琥珀氯霉素钠的动力学
Clin Pharmacol Ther. 1980 Jul;28(1):69-77. doi: 10.1038/clpt.1980.133.
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Oral chloramphenicol therapy.
J Pediatr. 1981 Dec;99(6):905-6. doi: 10.1016/s0022-3476(81)80014-5.
4
Typhoid fever. An epidemic with remarkably few clinical signs and symptoms.伤寒。一种临床体征和症状极少的流行病。
Arch Intern Med. 1984 Mar;144(3):533-7. doi: 10.1001/archinte.144.3.533.

正在接受口服或静脉制剂治疗的伤寒热患者血清中的氯霉素浓度。

Chloramphenicol concentrations in sera of patients with typhoid fever being treated with oral or intravenous preparation.

作者信息

Ti T I, Monteiro E H, Lam S, Lee H S

机构信息

Department of Pharmacology, Faculty of Medicine, National University of Singapore.

出版信息

Antimicrob Agents Chemother. 1990 Sep;34(9):1809-11. doi: 10.1128/AAC.34.9.1809.

DOI:10.1128/AAC.34.9.1809
PMID:2285296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171933/
Abstract

Serum chloramphenicol and chloramphenicol succinate concentrations in patients given equivalent doses of chloramphenicol base either intravenously or orally for typhoid fever were measured by high-performance liquid chromatography. The mean serum chloramphenicol concentrations were significantly lower in the 11 patients treated with intravenous chloramphenicol succinate than in the 15 patients treated with oral chloramphenicol capsules.

摘要

采用高效液相色谱法测定了伤寒热患者静脉注射或口服等量氯霉素碱后血清中氯霉素和琥珀氯霉素的浓度。11例接受静脉注射琥珀氯霉素治疗的患者血清氯霉素平均浓度显著低于15例口服氯霉素胶囊治疗的患者。