Ti T I, Monteiro E H, Lam S, Lee H S
Department of Pharmacology, Faculty of Medicine, National University of Singapore.
Antimicrob Agents Chemother. 1990 Sep;34(9):1809-11. doi: 10.1128/AAC.34.9.1809.
Serum chloramphenicol and chloramphenicol succinate concentrations in patients given equivalent doses of chloramphenicol base either intravenously or orally for typhoid fever were measured by high-performance liquid chromatography. The mean serum chloramphenicol concentrations were significantly lower in the 11 patients treated with intravenous chloramphenicol succinate than in the 15 patients treated with oral chloramphenicol capsules.
采用高效液相色谱法测定了伤寒热患者静脉注射或口服等量氯霉素碱后血清中氯霉素和琥珀氯霉素的浓度。11例接受静脉注射琥珀氯霉素治疗的患者血清氯霉素平均浓度显著低于15例口服氯霉素胶囊治疗的患者。