去铁胺和依氟鸟氨酸（DL-α-二氟甲基鸟氨酸）在卡氏肺孢子虫肺炎大鼠模型中的应用
Deferoxamine and eflornithine (DL-alpha-difluoromethylornithine) in a rat model of Pneumocystis carinii pneumonia.
作者信息
Clarkson A B, Sarić M, Grady R W
机构信息
Department of Medical and Molecular Parasitology, New York University Medical Center, New York 10016.
出版信息
Antimicrob Agents Chemother. 1990 Sep;34(9):1833-5. doi: 10.1128/AAC.34.9.1833.
Abstract
The iron chelator deferoxamine and the polyamine biosynthesis inhibitor eflornithine (DL-alpha-difluoromethylornithine) were examined for anti-Pneumocystis carinii activity in the rat model of P. carinii pneumonia. The activity of deferoxamine at 250, 500, and 1,000 mg/kg given intraperitoneally provides evidence that iron chelation is a promising novel approach to P. carinii chemotherapy. Results with eflornithine at 2, 3, and 4% in drinking water confirm and extend previously reported activity in the rat model.
摘要
在卡氏肺孢子虫肺炎大鼠模型中，对铁螯合剂去铁胺和多胺生物合成抑制剂依氟鸟氨酸（DL-α-二氟甲基鸟氨酸）的抗卡氏肺孢子虫活性进行了研究。腹腔注射250、500和1000mg/kg剂量的去铁胺的活性表明，铁螯合是卡氏肺孢子虫化疗的一种有前景的新方法。饮用水中依氟鸟氨酸浓度为2%、3%和4%时的实验结果证实并扩展了先前在大鼠模型中报道的活性。
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