在卡氏肺孢子虫肺炎大鼠模型中，通过临床可达到的血浆去铁胺浓度消除滋养体。
Trophozoite elimination in a rat model of Pneumocystis carinii pneumonia by clinically achievable plasma deferoxamine concentrations.
作者信息
Merali S, Chin K, Grady R W, Clarkson A B
机构信息
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10016, USA.
出版信息
Antimicrob Agents Chemother. 1996 May;40(5):1298-300. doi: 10.1128/AAC.40.5.1298.
Abstract
In a rat model of Pneumocystis carinii pneumonia, a 3-week infusion of deferoxamine producing concentrations in plasma of > or = 1.5 micrograms m-1 eliminated the trophozoite life cycle stage. Since this concentration is well below that routinely achieved in patients treated for iron overload, deferoxamine has promise as a therapy for AIDS-associated P.carinii pneumonia.
摘要
在卡氏肺孢子虫肺炎大鼠模型中，连续3周输注去铁胺使血浆浓度≥1.5微克/毫升，可消除滋养体生命周期阶段。由于该浓度远低于治疗铁过载患者时通常达到的浓度，去铁胺有望成为治疗艾滋病相关卡氏肺孢子虫肺炎的一种疗法。
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