首次采用不对称串联烯丙基化反应实现 (+)-(R)-Pinnatolide 的对映选择性全合成。
First enantioselective total synthesis of (+)-(R)-Pinnatolide using an asymmetric domino allylation reaction.
机构信息
Institute of Organic and Biomolecular Chemistry, Georg-August-University of Göttingen, Tammannstr. 2, D-37077 Göttingen, Germany.
出版信息
Org Lett. 2012 Aug 17;14(16):4035-7. doi: 10.1021/ol301932d. Epub 2012 Aug 2.
PMID:22853329
Abstract
An efficient total synthesis of (+)-(R)-Pinnatolide is described. As a key step an asymmetric multicomponent domino allylation reaction of methyl levulinate is used to form the quaternary stereogenic center in a highly selective way.
摘要
本文描述了（+）-（R）-Pinnatolide 的高效全合成。作为关键步骤，使用不对称多组分级联烯丙基化反应，以高度选择性的方式形成季立体中心。
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