Department of Community Health, Malaysian National University Medical Centre, Kuala Lumpur, Malaysia.
Subst Abuse Treat Prev Policy. 2012 Aug 1;7:32. doi: 10.1186/1747-597X-7-32.
Methadone Maintenance Therapy (MMT) is one of the popular choices for drug substitution therapy and is fairly new in Malaysia. Aside from its role in harm reduction against HIV infection, MMT programme may potentially enhances clients' quality of life. This study aims to identify the impact of MMT programme on clients' quality of life after 6 months in treatment and to explore factors that may be associated with changes in their quality of life.
In this retrospective report review, 122 subjects from 2 government MMT clinics were selected from the district of Tampin, Negeri Sembilan, Malaysia. The raw score from the WHO Quality of Life questionnaire (WHOQOL-BREF), at baseline and 6 months after therapy were collected and converted to 0-100 scale form to give quality of life scores for four domains; physical, psychological, social relationships and environment. Other variables of interest were socio-demography, age when joining MMT programme, age and duration of illicit drug use, HIV and Hepatitis C status, and the Opiate Treatment Index (OTI) score on drug use, sexual and social aspect at the baseline. Statistical analysis used the SPSS version 16.
There was significant improvement in all four domains of quality of life, after 6 months of MMT. The largest improvement was for psychological domain (mean score difference 15.54 ± 20.81). Multivariable linear regression analysis showed that, for the physical domain, there was no significant predictor. For both the psychological and social domains, having tertiary education is a significant predictor for improvement in both aspects of quality of life. Negative HIV status is associated with improvement for the environment domain.
There was a significant short term improvement in the quality of life of MMT clients who stayed in the programme for at least 6 months in the district of Tampin, Negeri Sembilan, Malaysia.
美沙酮维持疗法（MMT）是一种流行的药物替代疗法选择，在马来西亚相当新。除了在减少艾滋病毒感染方面的作用外，MMT 计划还有可能提高客户的生活质量。本研究旨在确定 MMT 计划在治疗后 6 个月对客户生活质量的影响，并探讨可能与生活质量变化相关的因素。
在这项回顾性报告回顾中，从马来西亚森美兰州淡边地区的 2 家政府 MMT 诊所中选择了 122 名受试者。在基线和治疗后 6 个月时收集了世界卫生组织生活质量问卷（WHOQOL-BREF）的原始分数，并转换为 0-100 量表形式，以给出四个领域的生活质量评分；身体、心理、社会关系和环境。其他感兴趣的变量包括社会人口统计学、加入 MMT 计划的年龄、非法药物使用的年龄和持续时间、艾滋病毒和丙型肝炎状态，以及基线时药物使用、性和社会方面的阿片类药物治疗指数（OTI）评分。统计分析使用 SPSS 版本 16。
在 MMT 治疗 6 个月后，所有四个生活质量领域都有显著改善。最大的改善是在心理领域（平均得分差异 15.54±20.81）。多变量线性回归分析表明，在身体领域，没有显著的预测因子。对于心理和社会领域，接受高等教育是改善生活质量的两个方面的重要预测因素。阴性艾滋病毒状态与环境领域的改善相关。
在森美兰州淡边地区，至少有 6 个月接受 MMT 治疗的患者的生活质量有显著的短期改善。
