National Center for AIDS/STD Control and Prevention, Beijing, China.
J Acquir Immune Defic Syndr. 2010 Feb;53 Suppl 1(Suppl 1):S116-20. doi: 10.1097/QAI.0b013e3181c7dfb5.
To explore the quality of life (QOL) changes in methadone maintenance treatment (MMT) clinic outpatients in the first 3 months of treatment.
A cohort study was conducted in 5 MMT clinics for more than 3 months, and the QOL of outpatients was measured by the QOL instrument for drug addicts at days 1, 30, and 90 to explore QOL changes. Repeated measurement analysis method was used for data analysis.
One hundred seventy-two outpatients in 5 MMT clinics were recruited, and 142 (82.65%) remained in treatment at day 90. The Cronbach alpha coefficient of the QOL instrument for drug addicts used in our study is 0.96, with a range of 0.74-0.94 for all subscales. The QOL scores of drug addicts improved from day 1 to day 30 (X(beginning) = 51.92, X(first month) = 74.83, P < 0.01), and all subscale scores improved significantly (P < 0.01). However, QOL improved little from day 30 to day 90, (X(first month) = 74.83, X(third month) = 75.99, P < 0.01). Physical health and mental health improved significantly during the second and third month, whereas all other subscale scores did not (P > 0.05).
MMT is helpful in improving the QOL of outpatients in MMT clinics in China.
探索美沙酮维持治疗（MMT）门诊患者在治疗的头 3 个月生活质量（QOL）的变化。
在 5 家 MMT 诊所进行了一项队列研究，超过 3 个月，通过吸毒者 QOL 量表在第 1、30 和 90 天测量门诊患者的 QOL，以探讨 QOL 的变化。采用重复测量分析方法进行数据分析。
在 5 家 MMT 诊所招募了 172 名门诊患者，其中 142 名（82.65%）在第 90 天仍在治疗中。本研究中使用的吸毒者 QOL 量表的 Cronbach alpha 系数为 0.96，所有分量表的范围为 0.74-0.94。吸毒者的 QOL 评分从第 1 天到第 30 天（X（开始）=51.92，X（第一个月）=74.83，P<0.01）有所提高，所有分量表评分均显著提高（P<0.01）。然而，从第 30 天到第 90 天，QOL 改善不大（X（第一个月）=74.83，X（第三个月）=75.99，P<0.01）。在第二个和第三个月，身体健康和心理健康显著改善，而其他所有分量表评分没有改善（P>0.05）。
MMT 有助于改善中国 MMT 诊所门诊患者的 QOL。
