Nat Cell Biol. 2012 Aug;14(8):786-8. doi: 10.1038/ncb2550.
Nutrient deprivation and other stress stimuli elicit metabolic changes (such as the induction of autophagy and activation of FOXO transcription factors) that help an organism adapt to stressful conditions. A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.
营养剥夺和其他应激刺激会引发代谢变化（如自噬的诱导和 FOXO 转录因子的激活），帮助生物体适应应激条件。这些应激反应途径之间的联系是通过发现 FOXO3 上调谷氨酰胺合成酶的表达来促进谷氨酰胺积累、抑制 mTOR 信号和促进自噬而揭示的。
