Numan M, McSparren J, Numan M J
Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02167.
Behav Neurosci. 1990 Dec;104(6):964-79. doi: 10.1037//0735-7044.104.6.964.
The lateral connections of the medial preoptic area (MPOA) are essential for maternal behavior in rats. The purpose of this study was to more exactly specify the nature of this pathway. Experiment 1 found that knife cuts that severed the dorsolateral connections of the MPOA were as effective as complete cuts in disrupting maternal behavior, whereas knife cuts that severed the ventrolateral MPOA connections were ineffective. These results suggest that MPOA efferents and afferents critical for maternal behavior leave or enter the MPOA dorsolaterally. Experiment 2 located possible sources of critical afferent input. Lactating rats received MPOA lateral cuts with a horseradish peroxidase (HRP)-coated wire knife. Full lateral cuts and dorsolateral cuts disrupted maternal behavior and labeled more cells with HRP in the nucleus of the solitary tract and the locus coeruleus than did ventrolateral cuts, which did not disrupt maternal behavior.
内侧视前区（MPOA）的外侧连接对于大鼠的母性行为至关重要。本研究的目的是更准确地明确该通路的性质。实验1发现，切断MPOA背外侧连接的刀割与完全切断在破坏母性行为方面同样有效，而切断MPOA腹外侧连接的刀割则无效。这些结果表明，对母性行为至关重要的MPOA传出纤维和传入纤维从背外侧离开或进入MPOA。实验2确定了关键传入输入的可能来源。给哺乳期大鼠用涂有辣根过氧化物酶（HRP）的线刀进行MPOA外侧切割。完全外侧切割和背外侧切割破坏了母性行为，并且与未破坏母性行为的腹外侧切割相比，在孤束核和蓝斑中用HRP标记的细胞更多。
