Miceli M O, Malsbury C W
Physiol Behav. 1982 May;28(5):856-67.
Parasagittal knife cuts with a varied mediolateral position were placed along the medial preoptic-medial anterior hypothalamic continuum (MPOA-MAH) in female hamsters. Near lateral (NL) knife cuts severed mediolateral connections between the MPOA-MAH and the medial forebrain bundle (MFB) while far lateral cuts (FL) were placed more laterally, sparing MPOA-MAH connections with the MFB. Across the knife cut condition, hamsters were either allowed to construct and maintain a food hoard or allowed to feed ad lib but not permitted to hoard. Animals were then tested for maternal behaviours. Both NL and FL cuts disrupted pup-directed behaviours in virgin maternal tests. NL, but not FL cuts severely disrupted nest building. These same animals were then mated and tested for maternal behaviour with their own young. There were no differences among the experimental groups in various maternal behaviours during these tests. Throughout lactation, however, the majority of NL and FL hamsters not permitted to hoard progressively cannibalized their entire litters. NL and FL counterparts with the hoarding opportunity, on the other hand, cannibalized fewer pups and reared healthy, moderate-sized litters that were smaller than those of surgical controls. That FL cuts were just as effective as NL cuts in disrupting pup-directed behaviour suggests that the mediolateral connections of the MPOA-MAH, other than with the MFB, are important for these behaviours.
在雌性仓鼠中，沿着内侧视前区-内侧下丘脑前部连续区域（MPOA-MAH）进行不同中外侧位置的矢状旁切口。近外侧（NL）切口切断了MPOA-MAH与内侧前脑束（MFB）之间的中外侧连接，而远外侧切口（FL）则更靠外侧，保留了MPOA-MAH与MFB的连接。在整个切口条件下，仓鼠要么被允许构建并维持一个食物储备，要么被允许自由进食但不允许储备食物。然后对动物进行母性行为测试。在未生育母鼠的测试中，NL和FL切口都破坏了针对幼崽的行为。NL切口而非FL切口严重破坏了筑巢行为。然后让这些相同的动物交配，并对它们与自己幼崽的母性行为进行测试。在这些测试中，各实验组在各种母性行为上没有差异。然而，在整个哺乳期，大多数不允许储备食物的NL和FL仓鼠逐渐吃掉了它们的全部幼崽。另一方面，有储备食物机会的NL和FL仓鼠吃掉的幼崽较少，养育出健康、中等大小的幼崽，这些幼崽比手术对照组的幼崽小。FL切口在破坏针对幼崽的行为方面与NL切口同样有效，这表明MPOA-MAH的中外侧连接，除了与MFB的连接外，对这些行为很重要。
