Department of Ophthalmology, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan.
Jpn J Ophthalmol. 2012 Sep;56(5):453-7. doi: 10.1007/s10384-012-0164-1. Epub 2012 Aug 2.
To report the clinical and histopathological features of a suspected case of fish-eye disease.
A 57-year-old man presented with blurred vision. The best corrected visual acuity was 0.8 OD and 1.0 OS. The patient had no family history of cloudy cornea. Slit-lamp examination revealed massive bilateral diffuse corneal clouding. Because of progressive corneal clouding during the previous 3 years, we performed penetrating keratoplasty and cataract surgery. He had a low-plasma, high-density lipoprotein (HDL) concentration. Histopathologically, numerous small vacuoles were dispersed, especially in the anterior corneal stroma. An electron microscope revealed distinct 0.2-3.0-μm lipid vacuoles with a conserved stromal structure.
We suspected a case of sporadic fish-eye disease in a Japanese patient. Lipid deposition needs to be considered as a cause of diffuse corneal opacity.
报告一例疑似鱼眼病的临床和组织病理学特征。
一名 57 岁男性因视力模糊就诊。最佳矫正视力右眼为 0.8，左眼为 1.0。该患者无混浊角膜的家族史。裂隙灯检查显示双侧弥漫性角膜混浊。由于过去 3 年中角膜混浊逐渐加重，我们进行了穿透性角膜移植和白内障手术。患者的血浆浓度低，高密度脂蛋白（HDL）浓度高。组织病理学检查显示，大量小泡散在分布，特别是在前部角膜基质中。电子显微镜显示明显的 0.2-3.0-μm 脂质空泡，基质结构保持不变。
我们怀疑该日本患者为散发性鱼眼病。脂质沉积需要考虑为弥漫性角膜混浊的原因之一。
