Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN S-XXI), Instituto Mexicano del Seguro Social (IMSS), Mexico D.F., Mexico.
Clin Transl Oncol. 2012 Aug;14(8):586-91. doi: 10.1007/s12094-012-0845-8. Epub 2012 Jul 11.
The purpose of this study is to determine the association between the BIK/NBK gene expression and estrogen receptor alpha expression.
We determined the association of BIK/NBK gene expression by real time quantitative reverse transcription polymerase chain reaction and estrogen receptor alpha expression by immunohistochemistry in samples of breast cancer tissue.
We found a statistically significant correlation of BIK/NBK gene expression with the estrogen receptor alpha expression (ρ = 0.751, p = 0.004). For verify differences of BIK/NBK gene expression among ERα+ and ERα- breast cancer tissues, Mann-Whitney U test was performed, obtaining significant differences.
BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients according to the estrogen receptor alpha expression.
本研究旨在确定 Bik/Nbk 基因表达与雌激素受体 α 表达之间的关联。
我们通过实时定量逆转录聚合酶链反应确定 Bik/Nbk 基因表达的相关性，并通过免疫组织化学法确定乳腺癌组织中雌激素受体 α 的表达。
我们发现 Bik/Nbk 基因表达与雌激素受体 α 表达呈显著正相关（ρ=0.751，p=0.004）。为了验证 ERα+和 ERα-乳腺癌组织中 Bik/Nbk 基因表达的差异，我们进行了 Mann-Whitney U 检验，结果显示存在显著差异。
根据雌激素受体 α 的表达，Bik/Nbk 基因表达可能对乳腺癌患者具有重要的临床意义，并提供预测、预后或治疗标志物。
