Noah P W
Department of Medicine Dermatology, College of Medicine, University of Tennessee, Memphis 38163.
Semin Dermatol. 1990 Dec;9(4):269-76.
The microflora of 297 psoriasis patients was extensively examined. Throat, urine, and skin surfaces from scalp, ears, chest, face, axillary, submammary, umbilical, upper back, inguinal crease, gluteal-fold, perirectal, vaginal, pubis, penis, scrotal, leg, hands, feet, finger, and toenail areas were cultured for aerobic bacteria, yeast, and dermatophytes. Antibody levels to streptococcal enzymes were performed (streptolysin-O, DNAse-B, hyaluronidase, STREPTOZYME). Giemsa smears and KOH preparations were also used to determine yeast and dermatophyte presence. Associated organisms thought to provoke a psoriatic attack were as follows: streptococcal groups A, B, C, D, F, G, S viridans, S pneumoniae; Klebsiella pneumoniae, oxytoca; Escherichia coli; Enterobacter cloacae, E aerogenes, E agglomerans; Proteus mirabilis, P vulgaris; Citrobacter freundii, C diversus; Morganella morganii; Pseudomonas aeruginosa, P maltiphilia, P putida; Serratia marcescens; Acinetobacter calbio aceticus, A luoffi; Flavobacterium specie; CDC groups Ve-1, Ve-2, E-o2; Bacillus subtilis, cereus; Staphylococcus aureus; Candida albicans, C parapsilosis; Torulopsis, glabrata; Rhodotorula and dermatophytes. One or more antistreptococal enzyme tests was positive in 50% of patients. Titers to hepatitis E were elevated in one patient and to HIV in two patients.
对297例银屑病患者的微生物群进行了广泛检查。对来自头皮、耳朵、胸部、面部、腋窝、乳房下、脐部、上背部、腹股沟皱襞、臀褶、直肠周围、阴道、耻骨、阴茎、阴囊、腿部、手部、足部、手指和脚趾甲区域的咽喉、尿液及皮肤表面进行需氧菌、酵母菌和皮肤癣菌培养。检测了抗链球菌酶的抗体水平（抗链球菌溶血素O、脱氧核糖核酸酶B、透明质酸酶、链激酶）。吉姆萨涂片和氢氧化钾制剂也用于确定酵母菌和皮肤癣菌的存在。被认为可引发银屑病发作的相关微生物如下：A、B、C、D、F、G组链球菌、草绿色链球菌、肺炎链球菌；肺炎克雷伯菌、产酸克雷伯菌；大肠杆菌；阴沟肠杆菌、产气肠杆菌、聚团肠杆菌；奇异变形杆菌、普通变形杆菌；弗氏柠檬酸杆菌、异型柠檬酸杆菌；摩根摩根菌；铜绿假单胞菌、嗜麦芽窄食单胞菌、恶臭假单胞菌；黏质沙雷菌；醋酸钙不动杆菌、洛菲不动杆菌；黄杆菌属；疾病控制与预防中心Ve-1、Ve-2、E-o2组；枯草芽孢杆菌、蜡样芽孢杆菌；金黄色葡萄球菌；白色念珠菌、近平滑念珠菌；光滑假丝酵母；红酵母属和皮肤癣菌。50%的患者一项或多项抗链球菌酶试验呈阳性。1例患者戊型肝炎抗体滴度升高，2例患者人类免疫缺陷病毒抗体滴度升高。
