Belobraydic K A, Qadri S M
Methods Find Exp Clin Pharmacol. 1986 Nov;8(11):675-8.
1386 isolates from clinical specimens were tested against imipenem by disc agar diffusion. The bacteria used in this study consisted of Escherichia coli, Enterobacter aerogenes, E. agglomerans, E. cloacae, Klebsiella pneumoniae, K. oxytoca, K. ozanae, Proteus mirabilis, P. vulgaris, Providencia stuartii, P. rettgeri, Acinetobacter calcoaceticus, Citrobacter diversus, C. freundii, Morganella morganii, Serratia liquefaciens, S. marcescens, Hafnia alvei, Aeromonas hydrophila, Pseudomonas aeruginosa, P. cepacia, P. maltophila, P. fluorescens, Staphylococcus aureus, S. epidermidis, S. saprophyticus, pneumococcus, Lancefield group A, B and D streptococci, viridans streptococci, diphtheroids and Bacillus species. In vitro activity of imipenem was compared with the following antibiotics: ampicillin, amikacin, carbenicillin, cefoperazone, cefoxitin, cephalothin, chloramphenicol, clindamycin, colistin, erythromycin, gentamicin, methicillin, penicillin, tetracycline, tobramycin, trimethoprim-sulfamethoxazole and vancomycin. Of the 819 strains of Enterobacteriaceae tested, 99.5% were susceptible to imipenem. Ninety-seven percent strains of P. aeruginosa were also susceptible to imipenem. All the 161 isolates of S. aureus and 116 of the 117 isolates of enterococci exhibited in vitro susceptibility to this antibiotic. All gram positive bacteria tested were inhibited by imipenem except 28% isolates of S. epidermidis and 5% isolates of S. agalactiae.
采用纸片琼脂扩散法对1386份临床标本分离株进行亚胺培南药敏试验。本研究中使用的细菌包括大肠杆菌、产气肠杆菌、聚团肠杆菌、阴沟肠杆菌、肺炎克雷伯菌、产酸克雷伯菌、鼻硬结克雷伯菌、奇异变形杆菌、普通变形杆菌、斯氏普罗威登斯菌、雷氏普罗威登斯菌、醋酸钙不动杆菌、差异枸橼酸杆菌、弗氏枸橼酸杆菌、摩根摩根菌、液化沙雷菌、黏质沙雷菌、蜂房哈夫尼亚菌、嗜水气单胞菌、铜绿假单胞菌、洋葱伯克霍尔德菌、嗜麦芽窄食单胞菌、荧光假单胞菌、金黄色葡萄球菌、表皮葡萄球菌、腐生葡萄球菌、肺炎球菌、A、B和D群链球菌、草绿色链球菌、类白喉杆菌和芽孢杆菌属。将亚胺培南的体外活性与以下抗生素进行比较：氨苄西林、阿米卡星、羧苄西林、头孢哌酮、头孢西丁、头孢噻吩、氯霉素、克林霉素、黏菌素、红霉素、庆大霉素、甲氧西林、青霉素、四环素、妥布霉素、复方磺胺甲恶唑和万古霉素。在819株肠杆菌科细菌中检测发现，99.5%对亚胺培南敏感。97%的铜绿假单胞菌菌株也对亚胺培南敏感。161株金黄色葡萄球菌和117株肠球菌中的116株对该抗生素表现出体外敏感性。除28%的表皮葡萄球菌分离株和5%的无乳链球菌分离株外，所有检测的革兰氏阳性菌均被亚胺培南抑制。
