Panton R W, Goldberg M F, Farber M D
Department of Ophthalmology, University of Illinois, Chicago 60612.
Br J Ophthalmol. 1990 Oct;74(10):595-600. doi: 10.1136/bjo.74.10.595.
A case control study was conducted to identify the systemic and ocular risk factors for retinal arterial macroaneurysms. Forty-three patients with 52 photographically confirmed macroaneurysms were located. Forty-three age-matched, race-matched concurrent control patients were also identified. The patients with macroaneurysms had decreased visual acuity (p less than 0.0001) and a higher prevalence of hypertension (p = 0.037), female sex (p = 0.099), and retinal vein occlusions (p = 0.055) than controls. In patients with both a macroaneurysm and venous occlusion there was a 12.0 times higher prevalence of macroaneurysms in the area of retina drained by the occluded vein (p less than 0.05). Common findings associated with macroaneurysms included retinal haemorrhage (81% of patients), retinal exudate (70%), vitreous haemorrhage (30%), macular involvement (30%), and distal arteriolar narrowing (26%). Arteriolar occlusion occurred spontaneously (8%) or after laser photocoagulation (16%).
开展了一项病例对照研究，以确定视网膜动脉大动脉瘤的全身和眼部危险因素。找到了43例经照片证实有52个大动脉瘤的患者。还确定了43名年龄匹配、种族匹配的同期对照患者。与对照组相比，患有大动脉瘤的患者视力下降（p<0.0001），高血压患病率更高（p = 0.037），女性患病率更高（p = 0.099），视网膜静脉阻塞患病率更高（p = 0.055）。在既有大动脉瘤又有静脉阻塞的患者中，阻塞静脉引流区域的大动脉瘤患病率高12.0倍（p<0.05）。与大动脉瘤相关的常见表现包括视网膜出血（81%的患者）、视网膜渗出（70%）、玻璃体积血（30%）、黄斑受累（30%）和小动脉远端狭窄（26%）。小动脉阻塞自发发生（8%）或在激光光凝后发生（16%）。
