线粒体 DNA 5178 C/A 多态性影响习惯性吸烟对中年日本男性血脂异常风险的影响。
Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
机构信息
Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
出版信息
Lipids Health Dis. 2012 Aug 2;11:97. doi: 10.1186/1476-511X-11-97.
BACKGROUND
Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects.
METHODS
A total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted.
RESULTS
For subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily.
CONCLUSIONS
The present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
背景
已有研究报道，几种遗传多态性可改变吸烟对血清脂质水平的影响。本研究旨在探讨与长寿相关的线粒体 DNA 5178（Mt5178）C/A 多态性是否会改变习惯性吸烟对中年日本男性发生血脂异常的风险的影响。
方法
从因常规体检而就诊的个体中选择了 394 名男性受试者（年龄 53.9±7.9 岁；均值±标准差）。在 Mt5178 C/A 基因分型后，进行了一项横断面研究，评估了 Mt5178 C/A 多态性与吸烟共同作用对低高密度脂蛋白（HDL）胆固醇血症、高低密度脂蛋白（LDL）胆固醇血症或高三酰甘油血症风险的影响。
结果
对于 Mt5178C 携带者，随着每日吸烟量的增加，发生低 HDL 胆固醇血症的风险增加（趋势 P=0.001）。另一方面，Mt5178A 基因型与低 HDL 胆固醇血症风险之间的关系似乎并不取决于每日吸烟量。对于 Mt5178A 携带者，随着每日吸烟量的增加，发生高 LDL 胆固醇血症或高三酰甘油血症的风险增加（趋势 P=0.017 和 P=0.002）。然而，Mt5178C 基因型与高 LDL 胆固醇血症或高三酰甘油血症风险之间的关系并不取决于每日吸烟量。
结论
本研究结果表明，Mt5178 C/A 多态性可调节习惯性吸烟对中年日本男性血脂异常发生风险的影响。
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