线粒体 DNA 5178C/A 多态性与饮酒联合作用对日本男性健康体检者估算肾小球滤过率的影响：一项横断面研究。
Combined effect of mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on estimated glomerular filtration rate in male Japanese health check-up examinees: a cross-sectional study.
机构信息
Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Tokyo 142-8555, Japan.
出版信息
BMC Nephrol. 2013 Feb 12;14:35. doi: 10.1186/1471-2369-14-35.
BACKGROUND
Prevention of chronic kidney disease (CKD) is a major public health issue. Although several studies have been performed on the association between alcohol consumption and CKD or renal function, it remains controversial. Numerous genetic polymorphisms have been reported to be associated with CKD and kidney function. Mitochondrial DNA cytosine/adenine (Mt5178 C/A) polymorphism is associated with longevity in Japanese. This polymorphism modifies the effects of alcohol consumption on blood pressure, risk of hypertension, serum triglyceride levels, risk of hyper-LDL cholesterolemia and serum uric acid levels. The objective of this study was to investigate whether Mt5178 C/A polymorphism modifies the effects of alcohol consumption on renal function in male Japanese health check-up examinees.
METHODS
A total of 394 male subjects aged 29-76 years were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effects of Mt5178 C/A polymorphism and habitual drinking on the risk of mildly decreased estimated glomerular filtration rate (eGFR) (<90 ml/min/1.73 m(2)) was conducted.
RESULTS
For Mt5178A genotypic men, habitual drinking may increase eGFR (P for trend = 0.003) or reduce the risk of mildly decreased eGFR (P for trend = 0.003). Daily drinkers had a significantly higher eGFR than non-drinkers (P = 0.005). The crude odds ratio for decreased eGFR was significantly lower in daily drinkers than in non-drinkers (odds ratio = 0.092, 95% confidence interval: 0.012-0.727, P = 0.024). On the other hand, for Mt5178C genotypic men, habitual drinking does not appear to affect eGFR.
CONCLUSION
The present results suggest a joint effect of Mt5178 C/A polymorphism and alcohol consumption on eGFR and the risk of mildly decreased eGFR in male Japanese subjects.
背景
预防慢性肾病（CKD）是一个主要的公共卫生问题。虽然已经有几项研究探讨了饮酒与 CKD 或肾功能之间的关系，但结果仍存在争议。大量的遗传多态性已被报道与 CKD 和肾功能有关。线粒体 DNA 胞嘧啶/腺嘌呤（Mt5178C/A）多态性与日本人的长寿有关。这种多态性改变了饮酒对血压、高血压风险、血清甘油三酯水平、高 LDL 胆固醇血症风险和血尿酸水平的影响。本研究的目的是探讨 Mt5178C/A 多态性是否改变了日本男性健康体检者饮酒对肾功能的影响。
方法
从到医院进行常规体检的个体中选择了 394 名年龄在 29-76 岁之间的男性受试者。Mt5178C/A 基因分型后，进行了一项横断面研究，评估 Mt5178C/A 多态性与习惯性饮酒对轻度估算肾小球滤过率（eGFR）降低（<90ml/min/1.73m2）风险的联合影响。
结果
对于 Mt5178A 基因型男性，习惯性饮酒可能会增加 eGFR（趋势 P=0.003）或降低轻度 eGFR 降低的风险（趋势 P=0.003）。与不饮酒者相比，每日饮酒者的 eGFR 显著更高（P=0.005）。与不饮酒者相比，每日饮酒者的 eGFR 降低的粗比值比显著降低（比值比=0.092，95%置信区间：0.012-0.727，P=0.024）。另一方面，对于 Mt5178C 基因型男性，习惯性饮酒似乎不会影响 eGFR。
结论
本研究结果提示 Mt5178C/A 多态性和饮酒对日本男性 eGFR 和轻度 eGFR 降低风险有联合作用。
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