Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Lipids Health Dis. 2011 Jun 25;10:105. doi: 10.1186/1476-511X-10-105.
Combined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia.
A total of 394 male subjects were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia was conducted.
For men with Mt5178C, alcohol consumption was significantly and negatively associated with the risk of hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol ≥ 140 mg/dl) (P for trend = 0.015). After adjustment for age, body mass index (BMI), habitual smoking, coffee consumption and use of antihypertensive medicine, the odds ratio (OR) for hyper-LDL cholesterolemia was significantly lower in daily drinkers with Mt5178C than non-drinkers with Mt5178C (OR = 0.360, 95% confidence intervals: 0.153-0.847). A significant and negative association between alcohol consumption and serum LDL cholesterol levels was also observed in Mt5178C genotypic men (P for trend < 0.01). On the other hand, the association between Mt5178A genotype and risk of hyper-LDL cholesterolemia does not appear to depend on alcohol consumption.
For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.
已有研究报道线粒体 DNA 5178（Mt5178）C/A 多态性与饮酒相结合对高血压或高尿酸血症风险的影响。本研究旨在探讨 Mt5178 多态性是否调节饮酒对血脂异常风险的影响。
从因常规体检就诊的个体中选择了 394 名男性受试者。进行 Mt5178 C/A 基因分型后，进行了一项横断面研究，评估 Mt5178 多态性与饮酒相结合对血脂异常风险的影响。
对于 Mt5178C 男性，饮酒与低密脂蛋白（LDL）胆固醇升高（血清 LDL 胆固醇≥140mg/dl）的风险呈显著负相关（趋势 P=0.015）。在校正年龄、体重指数（BMI）、习惯性吸烟、咖啡摄入量和降压药使用后，Mt5178C 男性中每日饮酒者发生高 LDL 血症的比值比（OR）显著低于 Mt5178C 非饮酒者（OR=0.360，95%置信区间：0.153-0.847）。Mt5178C 基因型男性饮酒与血清 LDL 胆固醇水平之间也存在显著负相关（趋势 P<0.01）。另一方面，Mt5178A 基因型与高 LDL 血症风险之间的关联似乎并不依赖于饮酒。
对于 Mt5178C 基因型男性，饮酒可能降低高 LDL 血症风险。
