Netherlands Cancer Institute, The Netherlands.
Radiother Oncol. 2012 Aug;104(2):139-42. doi: 10.1016/j.radonc.2012.07.010. Epub 2012 Aug 2.
In contrast to most new oncology treatments, wide clinical introduction of partial breast irradiation (PBI) is not based on level A trial evidence. Despite promising phase I/II data, new reports based upon large cohorts of patients mention more recurrences and/or complications from PBI compared with whole breast irradiation (WBI), necessitating more careful selection of patients for PBI while awaiting long term results of major clinical trials. In an attempt to improve this we give preoperative PBI within a prospective trial.
与大多数新型肿瘤治疗方法不同，部分乳房照射（PBI）的广泛临床应用并非基于 A 级临床试验证据。尽管有Ⅰ/Ⅱ期数据的支持，但基于大量患者的新报告提到 PBI 比全乳房照射（WBI）更易复发和/或出现并发症，因此需要在等待大型临床试验的长期结果的同时，更加仔细地选择 PBI 患者。为了改善这一点，我们在一项前瞻性试验中给予了术前 PBI。
