Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON, M5S 3H8, Canada.
Chem Soc Rev. 2013 Feb 21;42(4):1667-80. doi: 10.1039/c2cs35213c. Epub 2012 Aug 2.
Halogen bonds are noncovalent interactions in which covalently bound halogens act as electrophilic species. The utility of halogen bonding for controlling self-assembly in the solid state is evident from a broad spectrum of applications in crystal engineering and materials science. Until recently, it has been less clear whether, and to what extent, halogen bonding could be employed to influence conformation, binding or reactivity in the solution phase. This tutorial review summarizes and interprets solution-phase thermodynamic data for halogen bonding interactions obtained over the past six decades and highlights emerging applications in molecular recognition, medicinal chemistry and catalysis.
卤素键是非共价相互作用，其中共价键合的卤素充当亲电物种。卤素键在控制固态自组装中的应用范围广泛，在晶体工程和材料科学中得到了明显的体现。直到最近，人们还不太清楚卤素键是否以及在多大程度上可以用于影响溶液相中的构象、结合或反应性。本综述总结并解释了过去六十年中获得的有关卤素键相互作用的溶液相热力学数据，并强调了在分子识别、药物化学和催化等领域的新兴应用。
