Piedra Helena F, Plaza Manuel
Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica "Enrique Moles", Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Oviedo Julián Clavería 8 33006 Oviedo Spain
Chem Sci. 2024 Oct 23;15(45):19077-83. doi: 10.1039/d4sc06550f.
The first visible-light-induced protocol for the general preparation of alkenyl thiocyanates from alkenyl bromides is presented. The reaction is simple, proceeds under very mild conditions and demonstrates broad functional group tolerance. Additionally, a flow protocol was developed to enable efficient scale-up of alkenyl thiocyanate synthesis, further enhancing the practicality and value of the method. Importantly, these alkenyl thiocyanates serve as valuable building blocks for the construction of diverse families of sulfur-containing molecules through trifluoromethylations, cycloadditions, oxidations, and C-S or P-S bond forming reactions.
本文介绍了首个由烯基溴化物通用制备烯基硫氰酸酯的可见光诱导反应方案。该反应简单，在非常温和的条件下进行，并具有广泛的官能团耐受性。此外，还开发了一种连续流动反应方案，以实现烯基硫氰酸酯合成的高效放大，进一步提高了该方法的实用性和价值。重要的是，这些烯基硫氰酸酯可作为有价值的结构单元，通过三氟甲基化、环加成、氧化以及碳-硫或磷-硫键形成反应，构建各种含硫分子家族。
