Dermatological Clinic, Department of Clinical and Molecular Medicine, Polytechnic Marche University, IT-60200 Ancona, Italy.
Acta Derm Venereol. 2013 Mar 27;93(2):161-4. doi: 10.2340/00015555-1373.
The aim of this study is to assess the associations between chronic spontaneous urticaria (CSU), Helicobacter pylori infection and small intestinal bacterial overgrowth. Forty- eight patients with CSU were studied by scoring the urticaria activity and assesing the quality of life. Patients with H. pylori infection (n=11) or small intestinal bacterial overgrowth (n=13) were specifically treated for one week and clinically evaluated both before and 4 weeks after the eradication therapy. Eradication of H. pylori infection led to a significant improvement in CSU (p<0.002). In contrast, eradication of small intestinal bacterial overgrowth was not associated with any clinical improvement in CSU, despite the fact that these patients had statistically significant more urticaria activity at baseline. Thus there is no evidence to support the eradication of small intestinal bacterial overgrowth in CSU, but eradication of H. pylori infection may result in an improvement of the disease.
本研究旨在评估慢性自发性荨麻疹（CSU）、幽门螺杆菌感染和小肠细菌过度生长之间的关联。通过对荨麻疹活动度进行评分并评估生活质量，对 48 例 CSU 患者进行研究。对 H. pylori 感染（n=11）或小肠细菌过度生长（n=13）的患者进行了为期一周的特异性治疗，并在根除治疗前和 4 周后进行了临床评估。根除 H. pylori 感染可显著改善 CSU（p<0.002）。相比之下，尽管这些患者在基线时的荨麻疹活动度有统计学意义上的显著增加，但根除小肠细菌过度生长与 CSU 的任何临床改善均无关。因此，没有证据支持在 CSU 中根除小肠细菌过度生长，但根除 H. pylori 感染可能会改善疾病。
